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Three mechanisms of action

Changes in morphology and metabolism enable Mn-oxidizing bacteria from midoceanic ridge environment to counter metalinduced stress

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SIRT1 mediates FOXA2 breakdown by deacetylation in a nutrient-dependent manner

Enzyme-based linkers are utilized most commonly in ADCs: 8 out of 13 FDA-approved ADCs use a protease-cleavable linker, including the ADCs enfortumab vedotin and trastuzumab deruxtecan that have transformed the standard of care for metastatic urothelial and breast carcinomas 54